Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition
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Glucagon Like Peptide-1 Receptor Agonists Since 2005, GLP-1Ra have emerged as a highly effective drug class for glycemic control that also reduce the risk of cardiovascular events and promote weight loss [99]
[DOI] [PubMed] [Google Scholar] 45.Patel K, et al